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Compare that to direct hormone replacement, which tops off levels from the outside and can sometimes suppress the glands own output over time

The power to detect differences between the study groups is larger than what is projected here as we will measure most of the outcomes more than once and also use these repeated measurements in the same analyses, adjusting for interdependence within a child using mixed effects models, generalised estimating equations or other appropriate methods

QWO works by enzymatically breaking down the collagen-rich bands (fibrous septae) responsible for creating a dimple-like effect on the skin surface

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